IV ozone is one of the most healing therapies available...
IV Ozone Therapy
IV ozone therapy is a remarkable treatment that stimulates the body’s natural healing processes to address the root causes of disease. It can strengthen your immune system, enhance recovery, prevent illness, and even slow the aging process. IV ozone therapy works by improving oxygen utilization and boosting cellular energy, which can contribute to better health and resilience.
Health benefits of IV ozone therapy include:
- Tissue regeneration
- Immune system support
- Pathogen elimination
- Reduced inflammation
- Enhanced detoxification
- Improved circulation
Aspen Integrative Medical Center is home to Dr. Paul Despres, a Fellow of the American Academy of Ozonotherapy (AAOT) and one of Arizona’s most experienced physicians in ozone therapy. He develops personalized treatment plans using IV ozone therapy to support optimal health with minimal risk. Learn more below, or call our office today to schedule your IV ozone treatment!
What is IV ozone therapy?
IV ozone therapy utilizes an oxygen-ozone (O₃) gas mixture to support deep healing at a cellular level. Ozone, a highly active form of oxygen composed of three oxygen atoms, enhances oxygen utilization, boosts energy production, neutralizes free radicals, and helps protect organ health. It also strengthens the immune system by stimulating T cell function, enabling the body to fight infections more effectively. During IV ozone therapy, a patient’s blood is enriched with an oxygen-ozone mixture and reinfused into the body, stimulating natural healing processes. Ozone is not foreign to the body—white blood cells naturally produce ozone to combat viruses, bacteria, and fungi.
Who can benefit from IV ozone therapy?
IV ozone can be used safely and effectively for a variety of acute and chronic concerns including:
- Acute infections such as colds, flus, Covid-19, bladder infections, strep throat, pharyngitis, sinusitis, lung infections, gangrene, and other localized or systemic infections of the body.
- Chronic infections such as Lyme disease and other tick-borne co-infections, Long Covid-19, Epstein-Barr Virus (EBV), Shingles, HIV, Hepatitis, Herpes, and Candida.
- Acute and chronic pain
- Chronic fatigue
- Chronic inflammatory conditions
- Auto-immune disease
- Neurological disease
- Fibromyalgia
- Allergies and chemical sensitivities
- Chronic bladder conditions like interstitial cystitis
- Chronic kidney disease including renal failure – can increase kidney infiltration rate
- Gastrointestinal disorders
- Stroke, traumatic brain injury, and concussions
- Adjunctive cancer care
- Eczema and psoriasis
- Multiple sclerosis
- Macular degeneration
- Coronary artery disease and cardiovascular disease
- Diabetes
- Dementia
- Wound care
- Asthma and COPD
IV ozone therapy is also helpful for heathy individuals looking to:
- Enhance athletic performance
- Increase energy
- Prevent disease
- Reverse aging
“What is the most important nutrient in the body? OXYGEN. Since decreased oxygen utilization is the primary cause of degenerative disease, the treatment of all diseases including aging, auto-immune disorders, cancer, cardiovascular disease, etc. is maximally enhanced in the presence of optimal oxygen utilization. This is why ozone therapy can be used in virtually every disease.”
~Dr. Frank Shallenberger
We Offer the Most IV Ozone Options in Northern Arizona
STEP 1 - Choose the Best Ozone Procedure and Dose
Standard IV Ozone
Standard IV ozone is our most affordable option, delivering excellent results. The procedure involves drawing blood from a vein—either by syringe or gravity—mixing it with heparin in a saline IV bag, enriching it with oxygen-ozone gas, and then reinfusing it back into the body through the same vein.
Hyperbaric Multi-Pass IV Ozone
Hyperbaric multi-pass, aka ten-pass, is a more intensive yet cost-effective treatment for those needing multiple sessions. During the procedure, an IV line connects the patient to a hyperbaric ozone machine, which withdraws 150 mL of blood, enriches it with oxygen-ozone gas, and reinfuses it. Each cycle, known as a ‘pass,’ can be repeated up to 10 times in a single session.
EBOO
Extracorporeal Blood Ozonation and Oxygenation (EBOO) is the most advanced and powerful IV ozone therapy available. Similar to dialysis, this treatment cycles blood through an ozone machine while simultaneously filtering out toxins. EBOO is an excellent option for those seeking to address chronic conditions such as persistent infections, chronic fatigue, inflammatory disorders, and cardiovascular disease.
Treatment Time = 30 – 60 Minutes
Dose Range = 4.2 – 16.8 mg
Treatment Time = 60 Minutes
Dose Range = 14 – 140 mg
Treatment Time = 60 – 120 Minutes
Dose Range = 210 – 420 mg
STEP 2 - Choose the Appropriate Photobiomodulation Add-On to Enhance Treatment
Ultraviolet Blood Irradiation (UBI)
Ultraviolet Blood Irradiation (UBI) enhances your blood-ozone mix with UV light, helping to strengthen your immune system, boost cellular energy, and accelerate healing. We’ve been offering this highly effective and affordable alternative to the Hemealumen at Aspen for over seven years—with great results.
Hemealumen Polychromatic Device
Hemealumen is an innovative device that enhances your blood-ozone mix with six high-energy light sources—red, violet, infrared, green, UVA, and UVC. These lights pulse at specific frequencies tailored to the treatment, supporting exceptional and longer-lasting health benefits. Think of it as laser therapy and a Rife machine all in one machine, designed to accelerate healing from both acute and chronic conditions
FAQ About IV Ozone Therapy
Health Benefits and Research
There has been many published studies examining how ozone may be beneficial to the human body, including:
- Upregulates oxygen utilization and restore mitochondrial function.
- Decreases inflammation and modulates cytokines
- Anti-viral, bacterial, fungal, parasitic
- Enhances benefits of chemotherapy and radiation
- Activates Nrf2
- Increases nitric oxide
- Clears excess free radicals through activation of antioxidant enzyme systems
- Supports the immune system to fight infections by stimulating T cell function
- Improves circulation by enhancing the flow of your blood, breaking down plaques in arteries, and enhances red blood cell distensibility
- Promotes anti-aging and longevity
- Enhances athletic performance
- Increases detoxification
- Protects against neurodegeneration
- Increases energy levels and metabolism
- Modulates the immune system – calming down hyperactive or autoimmune disease or stimulating the immune system when it is under functioning (such as in cancer, chronic infections)
- Purifies blood and lymph
- Increases cellular glutathione levels
Yes! Ozone therapy is a well-researched, highly effective treatment that addresses root causes of illness with minimal safety risks. It has been extensively studied, with over 2,000 published medical papers supporting its benefits. For more than a century, ozone therapy has been safely and successfully used across Europe, Asia, and Latin America. In the United States, pioneers like Dr. Frank Shallenberger, Dr. Robert Rowen, and the American Academy of Ozonotherapy (AAOT) have advanced this field.
As we age or experience illness and toxic exposure, our body’s ability to use oxygen declines. This leads to poor mitochondrial function, reduced antioxidant production, and a buildup of free radicals. Excess free radicals contribute to organ degeneration, weakened immune function, cancer, and other degenerative diseases. Ozone therapy helps counteract these effects by improving oxygen utilization, boosting ATP production, neutralizing free radicals, and protecting organ health. It also strengthens the immune system by stimulating T cell function, helping the body fight infections more effectively.
Dr. Frank Shallenberger says it best, “Since decreased oxygen utilization is the primary cause of degenerative disease, the treatment of all diseases including aging, auto-immune disorders, cancer, cardiovascular disease, etc. is maximally enhanced in the presence of optimal oxygen utilization. This is why ozone therapy can be used in virtually every disease.”
About IV Ozone Treatment Options
Ultraviolet blood irradiation, also known as UBI, is a type of IV ozone therapy that involves withdrawal of 60-300 mL of blood, adding heparin to prevent clotting, and then adding it to an IV bag of saline. The provider then adds a certain volume and concentration of a pure ozone-oxygen mix to the IV bag. After mixing the bag for several minutes, the ozone-blood mix is “activated” and infused back into the patient passing through an ultraviolet machine. The UV light helps enhance the body’s immune response, improving its ability to fight infections, and reducing inflammation. Your provider may recommend an IV push of glutathione or other nutrients at the end of treatment to enhance the benefits and lessen side effects. Overall the patient visit is between 30-60 minutes. Patients typically report immediately feeling better or within 1-2 days. Your provider will recommend how often you get treatment to reach your health goals.
Multi-Pass High IV Ozone, aka “Ten-Pass”, involves using a machine that withdraws ~150 mL of the patient’s blood via an IV line into a sterile glass bottle with heparin, enriches it with a pure ozone-oxygen mix, and then returns the ozone-blood mixture to the patient back through the same vein. It can be done up to ten passes, hence the name, and is one the most powerful ozone treatment available. The treatment benefits can be further enhanced running the ozone-blood mixture through an “Ultraviolet Blood Irradiation” or “Hemealumen” as it infuses back into the patient. Overall the patient visit is between 30-60 minutes depending on how many passes is prescribed. Patients typically report feeling immediately better or within 1-2 days and the benefits can last for weeks. Your provider will recommend how often you get treatment and at what dose to reach your health goals.
Our clinic exclusively uses Zotzman from Germany and medical grade oxygen concentrators to insure highest purity.
The number of treatments will depend on your condition and the results you are looking to achieve. Some conditions will require more frequent and more numerous treatments while other acute concerns may resolve after just one treatment.
While ozone therapy is a very effective treatment, you will achieve more significant results if you combine it with other naturopathic modalities (like dietary/lifestyle changes, nutrient supplementation, physical medicine, and herbal medicine), so that the underlying causes of your disease are fully addressed.
If you have never done IV ozone before, we typically recommend starting with 1-2 passes of ozone. If well-tolerated we then can increase sequentially up to 10 passes, so you get the maximal health benefits from treatment
The EBOO procedure itself is similar to dialysis: 1-3 liters of blood is drawn from a vein, passes through a specialized filter where it is enriched with an oxygen-ozone gas mixture, and is then reintroduced into the body through a different vein. This filtration process removes debris from destroyed pathogens, heavy metals, fungi, and other impurities while ozonating the blood in stages.
Because EBOO is a closed system, the blood is never exposed to outside elements, eliminating the risk of contamination. The entire treatment—including catheter placement, therapy administration, and completion—typically takes 60 to 120 minutes. For patients with difficult-to-access veins, we use ultrasound guidance to ensure safe and effective catheter placement.
The Hemealumen is an advanced polychromatic device that enhances the benefits of IV ozone therapy by enriching your blood-ozone mixture with six high-energy light sources and pulsing frequencies similar to a Rife machine. This innovative approach provides exceptional support for both acute and chronic health concerns, including chronic fatigue, chronic infections, Long COVID-19, Lyme disease, mold illness, cardiovascular disease, and more.
Aspen Integrative Medical Center is the only clinic in Flagstaff offering this cutting-edge treatment, using it safely and effectively to promote deep healing.
- Basic foundations of health and healing such as sleep
- Diet and nutrition – avoiding food sensitivities and inflammatory foods
- Detoxification – especially heavy metals
- Hormone replacement – especially adrenal and thyroid gland function
- Stress management – manage the right amounts of coffee, alcohol, exercise, sleep, emotions, allergies, and sugar
- Eliminate foci – 4 major sources:
- 1.) Dental foci – periodontal issues, root canals, infected teeth, misalignment of jaw
- 2.) Sinuses – treat with ozone
- 3.) Gut and microbiome imbalance
- 4.) Scars – usually cutaneous surgical scars. Did you get sick after surgery?
What to Expect
We recommend the following for the best results, but not required:
– Hydrate: Be sure you are well hydrated (drink at least 32 oz of water in the 24 hours prior to your treatment)
– Eat Well: Eat a meal high in protein and healthy fats within 2 hours prior to your treatment. Limit/remove any highly processed or sugary foods.
– Avoid Supplements: Avoid taking any vitamins or minerals within 2 hours prior to your treatment.
– Attire: Wear a short sleeve shirt that provides easy access to both arms for placing the IV line.
– Rested: Do your best to come relaxed, low stress, and well-rested.
– Notification of Changes: Inform our office of any new or acute health concerns, medications, reactions, or general concerns since your last visit.
– Give Feedback: Your feedback between procedures is crucial for providing tailored and relevant treatment. Plan to share your feedback at each visit or over the phone prior to your next treatment
It can take 30-60 minutes depending on which type of IV ozone therapy you are prescribed.
Some patients report feeling better immediately while others report feeling better 1-2 days after treatment. Please know the ozonides from ozone therapy can persist in the body for 7-10 days, so there are on-going health benefits days after treatment. The benefits of ozone therapy are cumulative, so each additional treatment builds upon the prior treatment and treatment benefit typically lasts longer.
The number of treatments you will need depends on your condition and the results we are looking to achieve. Some conditions will require more frequent and more numerous treatments while other acute concerns may resolve after just one treatment. While ozone therapy is a very effective treatment, you will achieve more significant results if you combine it with other naturopathic modalities (like dietary/lifestyle changes, nutrient supplementation, physical medicine, and herbal medicine), so that the underlying causes of your disease are fully addressed.
If you don’t notice any benefit—or if you experience any negative reactions—from IV ozone therapy, it’s important to explore potential underlying reasons, such as:
- Nutrient deficiencies: Ozone therapy stimulates key enzymes and biochemical pathways, which require adequate vitamins and minerals to function properly.
- Genetic factors: Certain genetic variations (SNPs) may affect how your body responds to ozone.
- High infection or toxin load: Ongoing infections or toxin accumulation can interfere with your body’s ability to benefit from ozone therapy.
Our physicians at Aspen will carefully monitor your progress and response to treatment. When appropriate, we may recommend additional lab testing to better identify the root causes of an abnormal reaction or lack of response.
Safety and Contraindications
The degree of side effects varies depending on the patient’s individual health, the dose of ozone administered, and the severity of their condition. For example, patients with long-standing chronic illnesses like Long COVID or Lyme disease may experience a “healing reaction” (also known as a Herxheimer reaction or “herx”). This occurs when the immune system is stimulated, detox pathways are activated, and infections begin to die off. As a result, some patients may feel more fatigued immediately after treatment as the body prioritizes healing and recovery.
Other potential side effects may include:
- General IV-related effects such as transient low blood sugar, headache, lightheadedness, local swelling, bruising, or irritation at the catheter insertion site
- A temporary shift in the menstrual cycle
- Slight hemolysis (which may cause brownish or reddish urine)
To minimize side effects, consider:
- Staying well-hydrated
- Getting adequate rest
- Taking an Epsom salt bath, using a sauna, or doing a cold plunge
- Using anti-inflammatory supplements or medications as needed
- Eating a nutrient-dense meal with protein and healthy fats while limiting processed foods and sugars
If you experience any side effects, be sure to inform your doctor so they can provide appropriate guidance.
Yes, IV ozone therapy is extremely safe when performed by a trained, licensed medical professional using the highest-quality equipment. Side effects are rare, but some patients may experience temporary fatigue due to pathogen die-off or the activation of detoxification pathways—both considered positive healing responses.
While ozone therapy is highly safe, it is not suitable for everyone and is contraindicated in individuals with:
- G6PD deficiency
- Pregnancy or lactation
- Uncontrolled hyperthyroidism
- Active bleeding or acute hemorrhagic conditions
- Acute myocardial infarction (heart attack)
- Allergy to heparin
If you have any concerns about whether EBOO is right for you, consult with your doctor to ensure it is a safe and appropriate treatment for your condition.